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A potential breakthrough in the cure for mental illness.

Dr.Taiju Matsuzawa, Director of the Kunimigaoka Mirai Clinic, has propposed a new method of diagnosing depression, schizophrenia and dementia with subsequently more efficient use of medicine and methods of treatment, as summarized in the following article by the medical journalist, Isao Tanabe, in the science section of The Asahi newspaper.

 

It is well-known that patients suffering from mental illnesses such as schizophrenia, depression or dementia have to follow a life-long treatment. There are few patients who completely recover under current therapy, using mainly new developed psychiatric drugs from Japan or worldwide.
In fact, as the onset of schizophrenia often occurred at adolescence, the longstanding duration of drug use concomitant with the drugs’ side-effects decrease the chance of disease recovery. Since only a few numbers of patients would fully recover, the majority of patients would remain dependant in activities of daily living.
Recently, patients suffering from depression at an early stage benefit from new drugs such as “donepezil hydorochloride”. However, patients suffering from more advanced depression with longstanding drug use are more likely to be afflicted with serious drugs’ side-effects. The aetiology of geriatric dementia is still unclear but the development of new drugs for Alzheimer’s disease seems effective, though on advanced stages solely.
Professor Matsuzawa, a pioneer in the development of PET (Positron Emission Tomography) in cancer diagnosis, proposed a new approach in the treatment of mental illnesses. According to his expertise in cancer diagnosis as radiologist and clinician, he contributed a lot in PET performances in brain scanning. One of his new findings was remarkable and brought bright possibilities for mental patients to get relieved from their sufferings by possible fully recovery. Professor Matsuzawa found symmetric brain injuries at MRI(Magnetic Resonance Imaging) scanning. Injuries decreased with appropriate treatment and fully disappeared with complete recovery.
Mr. Isao Tanabe, medical journalist and former chief of the Medical Section at the Asahi Newspaper would like to introduce Professor Taiju Matsuzawa and some up-date information on treatment. Based on Professor Matsuzawa’s recent findings, the new treatment was successful in 90% of patients with depression or schizophrenia, and 70% with dementia. You are likely to be convinced through his scientific literature attached here in the reference list.


Information of the Kunimigaoka Mirai Clinic


1. Name of clinic: The Kumimigaoka Mirai Clinic

2. Location (see attached map) and access
*Location ( address)
1-9-8, Kunimigaoka, Aoba-ku, Sendai City 989-3201 Japan
Fax:81-22-725-6451 Phone: 81-22-719-1533

*Access:
15minutes by taxi from JR Sendai Station

3. Hours: 9:00 AM to 5: 00 PM
Monday, Tuesday, Thursday and Friday  
 (closed Wednesday , Japanese Holidays, Summer Holidays and New Year Holidays;
* Japanese Holidays (in year of 2010); July 19th(Mon), September 20th (Thu.), September 29th (Thu), October 11th(Mon), November 23rd(Tue), December 23rd(Thu)
*Summer Holidays; from August 11th (Mon) to 15th (Sun) (tentative)
* New Year Holidays; from December 28th (Tue) to January 5th(Wed) (tentative)

4. Fees:In overseas patients 150,000yen (about 1,600 u.s. dollars) for the first visit which includes MRI scan).

Patient information
In general, each patient is required and make an initial appointment by fax with written information (i.e. patient’s name, nationality, contact address, telephone & fax number, Email address, and projected date of visit). After the initial appointment in set, the patient will be asked to provide information on such things as current treatment (including names and dosages of drugs) and any noted beneficial results etc.

“There was a scar in the brain of depression sufferers”
Revolutionary Treatment Uses Eyeballs

By Isao Tanabe (a medical journalist)


“The existing treatment of psychiatric patients is not scientific and, therefore, has not been effective in curing illnesses. However, after years of research, I have found that depression sufferers have brain scars in common and curing the scars will lead to complete recovery from depression”. So says Dr. Taiju Matsuzawa (83), professor emeritus of radiology at Japan’s Tohoku University.

Dr. Matsuzawa has been studying brain images of the mentally ills since 1977 and is considered an expert in cancer diagnosis using PET (Positron Emission Tomography). Currently he is director of the Kunimigaoka Mirai Clinic, which specializes in the treatment of depression, schizophrenia and dementia.

“Traditionally, doctors have not used X-rays images of brains in diagnosing mental illnesses, and, since diagnosis is based upon what the patient tells the doctor, the same patient is often diagnosed with different illnesses depending upon the doctor who examines him. That is why we often have completely different results in the psychiatric evaluation of criminals in trials. However, if we base our diagnosis on brain images, we can not only treat patients properly but also develop a uniform diagnosis of their illnesses”, Dr. Matsuzawa explains.

Up to the present time psychiatry been an “art”, but Dr. Matsuzawa has introduced the “science” of image diagnostics into the field – a revolutionary accomplishment with the potential to shake the foundations of the entire profession. What is the secret of his treatment?

“I found that there is a unique scar in the amygdale in the brain of people who suffer from depression, schizophrenia” Matsuzawa said. This scar will clearly appear on the screen when shot from a unique angle Matsuzawa discovered.

Although depression and schizophrenia produce two scars on each side of the affected amygdale, the shape and exact location are different for the two illnesses. The scar for depression is round and located in upper area, while the one for schizophrenia is thinner and crescent-shaped and located in the lower region.

Up until now, psychiatrists have diagnosed depression and schizophrenia as two different illnesses and assigned one or the other to each patient. However, Matsuzawa found that many patients have four scars – a pair indicating depression and another pair for schizophrenia. Based on this finding, Matsuzawa believes that the two conditions are one and the same. He has named it “Compound Mental Illness”.

Most important, he has observed that although the telltale scars can enlarge or shrink, the symptoms only rarely occur once either has disappeared.

One of the benefits of this method of diagnosis is that one can actually see the effects of medication and the progress of treatment. In short, we are now able to treat mental illnesses – previously thought to have been “invisible” – as visible processes within the patient’s brain.

A man in his thirties, who suffered from depression for more than ten years, is now completely symptom-free thanks to this new approach. Matsuzawa, says “(His brain) looks completely different on MRI before and after treatment. He had two holes on both sides of his amygdale, but now we know that neurological stem cell can cure those holes”.

In diagnosing his patients, Dr. Matsuzawa also uses measures the level of serotonin and dopamine contained in the blood. It is a well-known fact that a lack of serotonin causes depression. At the same time, scientists have found that excessive levels of dopamine are a cause of schizophrenia. However, since there is a barrier between the brain and body that prevents the migration of these neurotransmitters into the bloodstream, researchers and physicians have paid little attention to the amount of serotonin in the blood.
Notwithstanding, Dr. Matsuzawa observes that patients suffering from Compound Mental Illness show smaller relative amounts of serotonin but greater amounts of dopamine. Based upon this, he conjectures that mental illnesses are caused by imbalances between these two agents.

“MRI and blood tests can tell whether depression or schizophrenia has been cured”, says Matsuzawa. In fact, there are several hundred patients he can point to who no longer need medication.

Matsuzawa’s method is quite simple. It uses essentially the same procedure for both depression and schizophrenia. First, he says, it is important to reduce the amount and variety of drugs prescribed. Depression sufferers may take many types of anti-depressants, but patients diagnosed with schizophrenia take far fewer drugs since it is considered a different illness. In contrast, Matsuzawa’s method gradually reduces the amount and types of medication, adds one medicine for schizophrenia, and eventually uses one type of each. Subsequently, he decreases the amount of both medications and at the same time monitors MRI images and blood test results until his patients are cured.

As part of the treatment, patients are advised to switch to a diet high in the amino acid tryptophan, which is converted to serotonin in the body. Recommended foods are soy beans, red meat, fish, bananas, pork and beef.

In addition he recommends a regimen of exercise. Based on MRI analysis, Matsuzawa believes a brain scar is repaired once neurological stem cells gather. Patients who exercise regularly tend to have quicker recovery, he claims. Exercise under the morning sun is preferred, but he does not recommend any particular type of exercise.

Matsuzawa contends his methods “have cured 90 percent of Compound Mental Illness patients within two to three years.” Let us hope that his method will dramatically change the field of psychiatry.

Dr. Matsuzawa has been studying brain images of the mentally ills since 1977 and is considered an expert in cancer diagnosis using PET (Positron Emission Tomography). Currently he is director of the Kunimigaoka Mirai Clinic, which specializes in the treatment of depression, schizophrenia and dementia.

“Traditionally, doctors have not used X-rays images of brains in diagnosing mental illnesses, and, since diagnosis is based upon what the patient tells the doctor, the same patient is often diagnosed with different illnesses depending upon the doctor who examines him. That is why we often have completely different results in the psychiatric evaluation of criminals in trials. However, if we base our diagnosis on brain images, we can not only treat patients properly but also develop a uniform diagnosis of their illnesses”, Dr. Matsuzawa explains.

Up to the present time psychiatry been an “art”, but Dr. Matsuzawa has introduced the “science” of image diagnostics into the field – a revolutionary accomplishment with the potential to shake the foundations of the entire profession. What is the secret of his treatment?

“I found that there is a unique scar in the amygdale in the brain of people who suffer from depression, schizophrenia”, Matsuzawa said. This scar will clearly appear on the screen when shot from a unique angle Matsuzawa discovered.

Although depression and schizophrenia produce two scars on each side of the affected amygdale, the shape and exact location are different for the two illnesses. The scar for depression is round and located in upper area, while the one for schizophrenia is thinner and crescent-shaped and located in the lower region.

Up until now, psychiatrists have diagnosed depression and schizophrenia as two different illnesses and assigned one or the other to each patient. However, Matsuzawa found that many patients have four scars – a pair indicating depression and another pair for schizophrenia. Based on this finding, Matsuzawa believes that the two conditions are one and the same. He has named it “Compound Mental Illness”.

Most important, he has observed that although the telltale scars can enlarge or shrink, the symptoms only rarely occur once either has disappeared.

One of the benefits of this method of diagnosis is that one can actually see the effects of medication and the progress of treatment. In short, we are now able to treat mental illnesses – previously thought to have been “invisible” – as visible processes within the patient’s brain.

A man in his thirties, who suffered from depression for more than ten years, is now completely symptom-free thanks to this new approach. Matsuzawa, says “(His brain) looks completely different on MRI before and after treatment. He had two holes on both sides of his amygdale, but now we know that neurological stem cell can cure those holes”.

In diagnosing his patients, Dr. Matsuzawa also uses measures the level of serotonin and dopamine contained in the blood. It is a well-known fact that a lack of serotonin causes depression. At the same time, scientists have found that excessive levels of dopamine are a cause of schizophrenia. However, since there is a barrier between the brain and body that prevents the migration of these neurotransmitters into the bloodstream, researchers and physicians have paid little attention to the amount of serotonin in the blood.
Notwithstanding, Dr. Matsuzawa observes that patients suffering from Compound Mental Illness show smaller relative amounts of serotonin but greater amounts of dopamine. Based upon this, he conjectures that mental illnesses are caused by imbalances between these two agents.

“MRI and blood tests can tell whether depression or schizophrenia has been cured”, says Matsuzawa. In fact, there are several hundred patients he can point to who no longer need medication.

Matsuzawa’s method is quite simple. It uses essentially the same procedure for both depression and schizophrenia. First, he says, it is important to reduce the amount and variety of drugs prescribed. Depression sufferers may take many types of anti-depressants, but patients diagnosed with schizophrenia take far fewer drugs since it is considered a different illness. In contrast, Matsuzawa’s method gradually reduces the amount and types of medication, adds one medicine for schizophrenia, and eventually uses one type of each. Subsequently, he decreases the amount of both medications and at the same time monitors MRI images and blood test results until his patients are cured.

As part of the treatment, patients are advised to switch to a diet high in the amino acid tryptophan, which is converted to serotonin in the body. Recommended foods are soy beans, red meat, fish, bananas, pork and beef.

In addition he recommends a regimen of exercise. Based on MRI analysis, Matsuzawa believes a brain scar is repaired once neurological stem cells gather. Patients who exercise regularly tend to have quicker recovery, he claims. Exercise under the morning sun is preferred, but he does not recommend any particular type of exercise.
Matsuzawa contends his methods “have cured 90 percent of Compound Mental Illness patients within two to three years.” Let us hope that his method will dramatically change the field of psychiatry.

 

 


CYRIC ANNUAL REPORT

Department of Nuclear Medicine and Radiology
Institute of Development, Aging and Cancer, Tohoku University, and
Department of Radiology, Kunimigaoka Mirai Clinic

 

 

 

 
 

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